Sandbox 43: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 23: | Line 23: | ||
HAMLET (human a-lactalbumin made lethal to tumor cells) is made up of partially unfolded α-lactalbumin and oleic acid (shown below). HAMLET has been shown to kill a wide range of tumor cells and embryonal cells but not healthy differentiated cells. It is thought that HAMLET initiate macroautophagy in tumor cells. HAMLET was shown to affect the mitochondria and to cause an apoptotic response with Cytochrome c release, low caspase activation, phosphatidylserine exposure and DNA fragmentation. HAMLET has also been shown to have no adverse effects ''in vivo''. HAMLET translocates to the nuclei, binding to histones and disrupts the function of chromatin in tumor cells<ref>Sonja Aits, Lotta Gustafsson, Oskar Hallgren, Patrick Brest, Mattias Gustafsson, Maria Trulsson, Ann-Kristin Mossberg, Hans-Uwe Simon, Baharia Mograbi and Catharina Svanborg. 2009. HAMLET (human a-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death. ''Int. J. Cancer'' 124, 1008–1019</ref> | HAMLET (human a-lactalbumin made lethal to tumor cells) is made up of partially unfolded α-lactalbumin and oleic acid (shown below). HAMLET has been shown to kill a wide range of tumor cells and embryonal cells but not healthy differentiated cells. It is thought that HAMLET initiate macroautophagy in tumor cells. HAMLET was shown to affect the mitochondria and to cause an apoptotic response with Cytochrome c release, low caspase activation, phosphatidylserine exposure and DNA fragmentation. HAMLET has also been shown to have no adverse effects ''in vivo''. HAMLET translocates to the nuclei, binding to histones and disrupts the function of chromatin in tumor cells<ref>Sonja Aits, Lotta Gustafsson, Oskar Hallgren, Patrick Brest, Mattias Gustafsson, Maria Trulsson, Ann-Kristin Mossberg, Hans-Uwe Simon, Baharia Mograbi and Catharina Svanborg. 2009. HAMLET (human a-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death. ''Int. J. Cancer'' 124, 1008–1019</ref> | ||
[[Image:Oleic_Acid2.gif]] | [[Image:Oleic_Acid2.gif]]<ref>scienceofcooking.com retrieved Sept. 20, 2009</ref> | ||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||
