Allosteric modulation of H-Ras GTPase
From Proteopedia
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| 3k8y, resolution 1.30Å (default scene) | |||||||||||||
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| Ligands: | ACT, CA, GNP, MG | ||||||||||||
| Gene: | HRAS, HRAS1 (Homo sapiens) | ||||||||||||
| Related: | 2rge, 3k9n, 3k9l | ||||||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
H-Ras is a small monomeric GTPase protein that is found inside of cells. It helps regulate cell division in cells through signal transduction pathways such as the Ras pathway. H-Ras is also known as a molecular switch, it contains two switch regions: Switch I and Switch II. Switch I is a Thymine 35 and switch II is a Glycine 60, both of these switches depend on the phosphate group on a GTP molecule to turn “on” and “off”. In the Ras catalytic cycle, Ras is activated when it attaches to a GTP molecule turning both switch regions “on”. This pathway also involves GTPase activating protein, which hydrolyzes the GTP attached to the Ras causing the switches to turn “off”.
