Ton

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The Ton System[1]

Structure

The Ton system comprises of the triumvirate TonB/ExbB/ExbD inner membrane complex.

Function

The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell.[2]

Interaction of Ton proteins

Like in the Tol complex, the Ton system proteins interact with each other[3]:

  1. the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane.
  2. ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction

Regulation

References

  1. ↑ Witty M, Sanz C, Shah A, Grossmann JG, Mizuguchi K, Perham RN, Luisi B. Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein. EMBO J. 2002 Aug 15;21(16):4207-18. PMID:12169623
  2. ↑ Cascales E, Buchanan SK, Duche D, Kleanthous C, Lloubes R, Postle K, Riley M, Slatin S, Cavard D. Colicin biology. Microbiol Mol Biol Rev. 2007 Mar;71(1):158-229. PMID:17347522 doi:10.1128/MMBR.00036-06
  3. ↑ Higgs PI, Myers PS, Postle K. Interactions in the TonB-dependent energy transduction complex: ExbB and ExbD form homomultimers. J Bacteriol. 1998 Nov;180(22):6031-8. PMID:9811664

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