2b3e | pdb_00002b3e
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Crystal structure of DB819-D(CGCGAATTCGCG)2 complex.
Overview
The crystal structure of the DNA minor groove biphenyl benzimidazole, diamidine ligand DB819 has been determined, bound to the DNA sequence, d(CGCGAATTCGCG)(2), at a resolution of 1.36 Angstrom. Conditions for, reliable in silico docking that reproduce the observed position of the, ligand in the minor groove have been determined.
About this Structure
2B3E is a Protein complex structure of sequences from [1] with MG and DBN as ligands. Full crystallographic information is available from OCA.
Reference
Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure., Campbell NH, Evans DA, Lee MP, Parkinson GN, Neidle S, Bioorg Med Chem Lett. 2006 Jan 1;16(1):15-9. Epub 2005 Nov 2. PMID:16263285
Page seeded by OCA on Tue Jan 29 18:15:35 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Protein complex
- Campbell, N.H.
- Evans, D.A.
- Lee, M.P.
- Neidle, S.
- Parkinson, G.N.
- DBN
- MG
- A2t2
- Crystal structure of b-dna
- Db819
- Dickerson and drew dodecamer
- Dna
- Dna hydration.
- Dna minor
- Dna minor groove-ligand complex
- Dna-drug complex
- Double helix
- Groove binder
- Hydrated magnesium
- Magnesium-water complex
- Minor groove
- Nucleic acids
