2cb2 | pdb_00002cb2
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SULFUR OXYGENASE REDUCTASE FROM ACIDIANUS AMBIVALENS
Overview
Numerous microorganisms oxidize sulfur for energy conservation and, contribute to the global biogeochemical sulfur cycle. We have determined, the 1.7 angstrom-resolution structure of the sulfur oxygenase reductase, from the thermoacidophilic archaeon Acidianus ambivalens, which catalyzes, an oxygen-dependent disproportionation of elemental sulfur. Twenty-four, monomers form a large hollow sphere enclosing a positively charged, nanocompartment. Apolar channels provide access for linear sulfur species., A cysteine persulfide and a low-potential mononuclear non-heme iron site, ligated by a 2-His-1-carboxylate facial triad in a pocket of each subunit, constitute the active sites, accessible from the inside of the sphere. The, iron is likely the site of both sulfur oxidation and sulfur ... [(full description)]
About this Structure
2CB2 is a [Single protein] structure of sequence from [Acidianus ambivalens] with FE as [ligand]. Full crystallographic information is available from [OCA].
Reference
X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme., Urich T, Gomes CM, Kletzin A, Frazao C, Science. 2006 Feb 17;311(5763):996-1000. PMID:16484493
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Proteopedia Page Contributors and Editors (what is this?)
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- Acidianus ambivalens
- Single protein
- Frazao, C.
- Gomes, C.M.
- Kletzin, A.
- Urich, T.
- FE
- 2-his-1-carboxylate facial triad
- Acidophilic
- Archaea
- Biogeochemical sulfur cycle
- Compartmentalization
- Cysteine persulphide
- Extremophile
- Icosatetramer
- Metal-binding
- Mononuclear non-heme iron
- Nano-structure
- Oxidoreductase
- Proto-organelle
- Sulfur oxygenase reductase
- Thermophilic
