2r7g | pdb_00002r7g

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File:2r7g.png

Template:STRUCTURE 2r7g

Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain

Template:ABSTRACT PUBMED 17974914

Disease

Known disease associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]

About this Structure

2R7G is a 5 chains structure of sequences from Homo sapiens and Human adenovirus 5. Full crystallographic information is available from OCA.

Reference

  1. Liu X, Marmorstein R. Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914 doi:21/21/2711

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