2n6h | pdb_00002n6h

NMR structure for a 2-stranded parallel beta-sheet

spinqualitylabelsall models 2n6h Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2n6h is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 10 models Ligands: 4G6, ACE, DPR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We have examined whether parallel beta-sheet secondary structure becomes more stable as the number of beta-strands increases, via comparisons among peptides designed to adopt two- or three-stranded parallel beta-sheet conformations in aqueous solution. Our three-strand design is the first experimental model of a triple-stranded parallel beta-sheet. Analysis of the designed peptides by nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy supports the hypothesis that increasing the number of beta-strands, from two to three, increases the stability of the parallel beta-sheet. We present the first experimental evidence for cooperativity in the folding of a triple-stranded parallel beta-sheet, and we show how minimal model systems may enable experimental documentation of characteristic properties, such as CD spectra, of parallel beta-sheets. Impact of Strand Number on Parallel beta-Sheet Stability.,Kung VM, Cornilescu G, Gellman SH Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14336-9. doi: 10.1002/anie.201506448. , Epub 2015 Oct 12. PMID:26457984 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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