Structural highlights
Function
RFIP3_HUMAN Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.[1] [2] [3]
References
- ↑ Wilson GM, Fielding AB, Simon GC, Yu X, Andrews PD, Hames RS, Frey AM, Peden AA, Gould GW, Prekeris R. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol Biol Cell. 2005 Feb;16(2):849-60. Epub 2004 Dec 15. PMID:15601896 doi:10.1091/mbc.E04-10-0927
- ↑ Horgan CP, Oleksy A, Zhdanov AV, Lall PY, White IJ, Khan AR, Futter CE, McCaffrey JG, McCaffrey MW. Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. Traffic. 2007 Apr;8(4):414-30. PMID:17394487 doi:https://dx.doi.org/10.1111/j.1600-0854.2007.00543.x
- ↑ Jing J, Tarbutton E, Wilson G, Prekeris R. Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. Eur J Cell Biol. 2009 Jun;88(6):325-41. doi: 10.1016/j.ejcb.2009.02.186. Epub, 2009 Mar 26. PMID:19327867 doi:https://dx.doi.org/10.1016/j.ejcb.2009.02.186
