36nb

Crystal structure of the NKX2-1 homeodomain bound to a palindromic DNA recognition sequence

spinqualitylabelsall models 36nb, resolution 3.26Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 36nb is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.26Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease NKX21_HUMAN Benign hereditary chorea;Differentiated thyroid carcinoma;Athyreosis;Brain-lung-thyroid syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. Function NKX21_HUMAN Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).[UniProtKB:P23441][UniProtKB:P50220]

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