| Structural highlights
4x7r is a 2 chain structure with sequence from Staphylococcus aureus subsp. aureus 21178. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 2.15Å |
| Ligands: | 3YW, BDP, IDS, PRD_900028, SGN, SUS, UDP, ZDO |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
TARM_STAAC Attaches N-acetyl-alpha-D-glucosamine residues to poly(RboP)-wall teichoic acids (WTAs).[1] [2] [3]
References
- ↑ Xia G, Maier L, Sanchez-Carballo P, Li M, Otto M, Holst O, Peschel A. Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM. J Biol Chem. 2010 Apr 30;285(18):13405-15. PMID:20185825 doi:10.1074/jbc.M109.096172
- ↑ Sobhanifar S, Worrall LJ, Gruninger RJ, Wasney GA, Blaukopf M, Baumann L, Lameignere E, Solomonson M, Brown ED, Withers SG, Strynadka NC. Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E576-85. doi:, 10.1073/pnas.1418084112. Epub 2015 Jan 26. PMID:25624472 doi:https://dx.doi.org/10.1073/pnas.1418084112
- ↑ Koc C, Gerlach D, Beck S, Peschel A, Xia G, Stehle T. Structural and enzymatic analysis of TarM from Staphylococcus aureus reveals an oligomeric protein specific for the glycosylation of wall teichoic acid. J Biol Chem. 2015 Feb 19. pii: jbc.M114.619924. PMID:25697358 doi:https://dx.doi.org/10.1074/jbc.M114.619924
|
