6cnz | pdb_00006cnz

Crystal Structure of Chorismate Mutase from Burkholderia thailandensis

spinqualitylabelsall models 6cnz, resolution 2.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6cnz is a 6 chain structure with sequence from Burkholderia thailandensis. This structure supersedes the now removed PDB entry 4oj7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.15Å Ligands: EDO, NO3 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A1B4JXW9_BURTH Catalyzes the Claisen rearrangement of chorismate to prephenate.[PIRNR:PIRNR026640] Publication Abstract from PubMed Burkholderia thailandensis is often used as a model for more virulent members of this genus of proteobacteria that are highly antibiotic-resistant and are potential agents of biological warfare that are infective by inhalation. As part of ongoing efforts to identify potential targets for the development of rational therapeutics, the structures of enzymes that are absent in humans, including that of chorismate mutase from B. thailandensis, have been determined by the Seattle Structural Genomics Center for Infectious Disease. The high-resolution structure of chorismate mutase from B. thailandensis was determined in the monoclinic space group P21 with three homodimers per asymmetric unit. The overall structure of each protomer has the prototypical AroQgamma topology and shares conserved binding-cavity residues with other chorismate mutases, including those with which it has no appreciable sequence identity. Crystal structure of chorismate mutase from Burkholderia thailandensis.,Asojo OA, Dranow DM, Serbzhinskiy D, Subramanian S, Staker B, Edwards TE, Myler PJ Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):294-299. doi:, 10.1107/S2053230X1800506X. Epub 2018 Apr 16. PMID:29717997 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also 3D structures of chorismate mutase

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