7fj1 | pdb_00007fj1

Cryo-EM structure of pseudorabies virus C-capsid

Loading... Status: waiting for Mol* initialization Structural highlights 7fj1 is a 51 chain structure with sequence from Suid alphaherpesvirus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.43Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G3G8T2_SUHV Publication Abstract from PubMed Pseudorabies virus (PRV) is a major etiological agent of swine infectious diseases and is responsible for significant economic losses in the swine industry. Recent data points to human viral encephalitis caused by PRV infection, suggesting that PRV may be able to overcome the species barrier to infect humans. To date, there is no available therapeutic for PRV infection. Here, we report the near-atomic structures of the PRV A-capsid and C-capsid, and illustrate the interaction that occurs between these subunits. We show that the C-capsid portal complex is decorated with capsid-associated tegument complexes. The PRV capsid structure is highly reminiscent of other alpha-herpesviruses, with some additional structural features of beta- and gamma-herpesviruses. These results illustrate the structure of the PRV capsid and elucidate the underlying assembly mechanism at the molecular level. This knowledge may be useful for the development of oncolytic agents or specific therapeutics against this arm of the herpesvirus family. Structures of pseudorabies virus capsids.,Wang G, Zha Z, Huang P, Sun H, Huang Y, He M, Chen T, Lin L, Chen Z, Kong Z, Que Y, Li T, Gu Y, Yu H, Zhang J, Zheng Q, Chen Y, Li S, Xia N Nat Commun. 2022 Mar 22;13(1):1533. doi: 10.1038/s41467-022-29250-3. PMID:35318331 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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