8uke

Crystal Structure of Norbelladine O-methyltransferase variant in complex with SAH

spinqualitylabelsall models 8uke, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8uke is a 6 chain structure with sequence from Narcissus aff. pseudonarcissus MK-2014. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.4Å Ligands: CA, SAH Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function NOMT_NARAP 4'-O-methyltransferase converting norbelladine to 4'-O-methylnorbelladine. 4'-O-methylnorbelladine is a precursor to all Amaryllidaceae alkaloids such as galanthamine, lycorine and haemanthamine, and including haemanthamine- and crinamine-type alkaloids, promising anticancer agents. Can use norbelladine, N-methylnorbelladine and dopamine as substrate, but not caffeic acid, vanillin, 3,4-dihydroxybenzaldehyde and tyramine.

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