Death-associated protein (DAP) or death domain-associated protein is associated with multiple cellular functions.
- DAP3 is known as mitochondrial small subunit ribosomal protein S29. Over-expression of DAP3 induces apoptosis in several cell lines.[1]
- DAP6 or Daxx interacts with apoptosis antigen. It has both pro- and anti-apoptosis functions.[2]
- DAP5 is an inhibitor of translational initiation in differentiation and apoptosis. For more details on DAP5 see Death Associated Protein 5.
3D structures of death-associated protein
Death-associated protein 3D structures
- ↑ Han MJ, Chiu DT, Koc EC. Regulation of mitochondrial ribosomal protein S29 (MRPS29) expression by a 5'-upstream open reading frame. Mitochondrion. 2010 Apr;10(3):274-83. PMID:20079882 doi:10.1016/j.mito.2009.12.150
- ↑ Yang X, Khosravi-Far R, Chang HY, Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997 Jun 27;89(7):1067-76. PMID:9215629
