Hepatocyte growth factor activator

spinqualitylabelsall models Human hepatocyte growth factor activator (magenta) complex with HGFA inhibitor type 1 (green) and phosphate (PDB code 1yc0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Hepatocyte growth factor activator (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury. Relevance Lower activity of HGFA results in impaired regeneration of damaged mucosal epithelium and may contribute to the progression of fibrotic lung cancer. Structural highlights HGFA substrate binding cleft resembles other trypsin-like serine proteases with inhibitors of the Kunitz type (α/β folds rich in Cys-Cys bonds) .

3D Structures of hepatocyte growth factor activator

Updated on 15-May-2019

1ybw – hHGFA protease domain – human
1yc0 – hHGFA protease domain + Kunitz-type protease inhibitor
2r0l, 2r0k, 2wub, 2wuc, 3k2u – hHGFA protease domain + antibody

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Michal Harel, Alexander Berchansky, Joel L. Sussman