Rac GTPase-activating protein

spinqualitylabelsall models Human Rac GTPase-activating protein 1 GAP domain (grey) complex with CDC42 (green) and GDP (PDB code 5c2j) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Rac GTPase-activating protein 1 (RacGAP1) is required for the attachment of the midbody to the cell membrane during cytokinesis. It is involved in the regulation of growth-related processes in adipocytes and myoblasts. Relevance RacGAP1 expression is a prognostic marker for HBV-positive human hepatocellular carcinoma and can be a potential molecular target for therapeutic strategies against this carcinoma.

3D structures of Rac GTPase-activating protein 1

Updated on 16-September-2026

2ovj, 3iug, 3w6r – hRICS GAP domain 348-546 – human
3wpq, 3wps – hRICS GAP domain (mutant)
4b6d – hRICS C1 domain 284-339
5c2j – hRICS GAP domain + CDC42 + GDP

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Michal Harel