Ras GTPase activating protein

spinqualitylabelsall models Human Ras GTPase activating protein dimer SH3 domain (PDB code 2j05). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ras GTPase activating protein (RasGAP) inactivates Ras from its active GTP-bound form to its GDP-bound form. It is part of the mitogenic signal transmission via its N-terminal SH2-SH3-SH2 domains. SynGAP is a neuronal RasGAP expressed in brain and negatively regulates Ras activity and its signaling pathways. Relevance Inactivated RasGAP activate RAS which is mutated in 30% of cancer types. RasGAP Colra1 is involved in infection-related morphogenesis in gourd family plants.

3D Structures of Ras GTPase activating protein

Updated on 22-September-2026

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• RsGAP; domains – SH3 N-terminal 58-118; SH2 N-terminal 174-280; SH3 C-terminal 281-341; SH2 C-terminal 341-446; C2 342-713; catalytic 714-1047
  • 2gqi – hRasGAP SH3 domain – human – NMR
    
  • 2j05, 2j06, 4fss - hRasGAP SH3 domain
    
  • 2m51, 7tpb – hRasGAP SH3 domain + DLC1 RhoGAP domain 671-880
    
  • 2gsb, 6wax - hRasGAP C-terminal SH2 domain – NMR
    
  • 6pxb - hRasGAP N-terminal SH2 domain
    
  • 6pxc - hRasGAP N-terminal SH2 domain + RhoGAP peptide
    
  • 6way - hRasGAP C-terminal SH2 domain + RhoGAP peptide
    
  • 8dgq - hRasGAP 174-444 + RhoGAP peptide
    
  • 6wax - hRasGAP C-terminal SH2 domain (mutant)
    
  • 2gsb - hRasGAP SH2 domain – NMR
    
  • 9bz4 - hRasGAP C2+catalytic domain
    
  • 1wer - hRasGAP catalytic domain
    
  • 1wq1, 8bos - hRasGAP catalytic domain + H-Ras
    
• RasGAP SynGAP
  • 3bxj - SynGAP C2-GAP fragment 252-734 - rat
    
  • 5jxc - SynGAP coiled-coil domain 1171-1258 - mouse
    

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