Sandbox 31

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. Adenylate Kinase (PDB ID #: 1ake) spinqualitylabelsall models adenylate kinase bound to non-hydrolyzable substrate analogue Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Introduction Adenylate Kinase is a good little protein. Physical Properties Adenylate kinase is caged with water molecules. I can add headings This is the AK scene. Structure The secondary structure of adenylate kinase shows alpha helices (cyan) and beta sheets (green) surrounding the non-hydrolysable substrate analogue (orange). A network of hydrogen bonds hold the secondary structural elements together. You can see the regular hydrogen bonding pattern in the alpha helices. Adenylate kinase has a hydrophilic exterior, and a hydrophobic core, with additional hydrophilic residues on the interior contacting the ligand. helix and sheet Active Site and Mechanism residues within 3 angstroms of the ligand are involved in binding the ligand or stabilizing the active site. adenylate kinase's active site is highlighted in dark blue. together you can see that the active site is only a fraction of the molecules involved in binding the ligand. spinqualitylabelsall models Cryptosporidium parvum Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Comparing the E.coli structure to Cryptosporidium parvum References Rhodopsin ball and stick