Sandbox 70

Please do NOT make changes to this Sandbox until after April 30, 2009. Sandboxes 60-80 are reserved until then for use by students of East High, Buffalo NY.

About Topoisomerases

You may wonder about the structure of DNA such as is it tangled or does it become stressed? Well the answer is yes but there a protein that relaxes and untangles DNA,it is called Topoisomerases.Topoisomerases is a protein that untangles and relax DNA.

Function

Topoisomerases wraps itself around DNA and makes a cut in one strand. While holding that damaged area, the enzyme allows the helix to spin, relaxing any tangled or untangled. After DNA relaxed,topoisomerase reconnects the broken strand, then returning DNA double helix back.

Structural Properties

Topoisomerases is mostly apla heliex,it also has beta sheet's and that concect each other. So there primary

and secondary and 3rd level and maybe the 4th levl of structure

1a36, resolution 2.80Å (default scene)

Activity:

DNA topoisomerase, with EC number 5.99.1.2

Structural annotation:
Resources:	CATH : 1A36A03, 1A36A02, 1A36A01, 1A36A04 InterPro : Ipr011010, Ipr009054, Ipr013500, Ipr013499, Ipr001631, Ipr013030, Ipr008336, Ipr014727, Ipr014711 Pfam : PF02919, PF01028 SCOP : d1a36a2, d1a36a1, d1a36a3 UniProt : P11387

Functional annotation:
Cellular component:	nucleolus perikaryon chromosome nucleoplasm cytoplasm nucleus
Biological process:	DNA unwinding during replication response to drug embryonic cleavage phosphorylation DNA topological change programmed cell death DNA replication
Molecular function:	DNA topoisomerase activity DNA topoisomerase (ATP-hydrolyzing) activity DNA binding chromatin binding protein binding isomerase activity DNA topoisomerase type I activity