Sarcosine oxidase

spinqualitylabelsall models Heterotetramer of sarcosine oxidase containing FAD, FMN and NAD showingα subunit (grey), β subunit (green), γ subunit (pink) and δ subunit (yellow). Complex with pyrrole-2-carboxylate, sulfate and Zn+2 ions (grey) 3ad8 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Sarcosine oxidase (SOX) catalyzes the demethylation of sarcosine+O2+H4-tetrahydrofolate to produce glycine, hydrogen peroxide and 5, 10-methylene-tetrahydrofolate. Sarcosine metabolism can be the source of carbon and energy for many microorganisms. SOXs are found as monomers, heterodirmers and heterotetramers. Monomeric SOX uses FAD as cofactor. Heterotetrameric SOX uses FAD and FMN as cofactors.

3D structures of sarcosine oxidase

Updated on 15-March-2022

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• Monomeric sarcosine oxidase
  • 1el5, 1el7, 1el8, 1el9, 1eli, 2gf3 – BaSOX + inhibitor – Bacillus
    
  • 1l9c, 1l9d, 1l9e, 3bhf, 3bhk, 3m0o, 3m12, 3m13 – BaSOX (mutant)
    
  • 2a89, 2gb0, 1zov, 3qsm, 3qss - BaSOX
    
  • 3qse – BaSOX + arcosine
    
  • 1y56 – SOX + protein – Pyrococcus horikoshii
    
  • 7exs – SOX (mutant) – Thermomicrobium roseum
    
• Sarcosine oxidase heterotetramer
  • 1vrq – CoSOX + folinic acid – Corynebacterium
    
  • 3ad7 – CoSOX + methylthio acetate
    
  • 3ad8 – CoSOX + pyrrole 2-carboxylate
    
  • 3ada – CoSOX + sulfite
    
  • 1x31, 3ad9 – CoSOX
    
  • 2gag, 2gah – SOX + furoic acid – Stenotrophomonas maltophilia

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