Transducin

spinqualitylabelsall models Structure of rat transducinα (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code 1gp2). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Transducin (TDN) or Heterotrimeric G protein or Guanine nucleotide-binding protein G is a heterotrimeric G protein containing 3 chains: α, β and γ which are organized in two subunits: α and βγ. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the GDP bound to its α subunit is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit. Disease Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit. 3D structures of transducin Transducin 3D structures

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