Integrin

spinqualitylabelsall models Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Integrins (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain.

3D structures of integrin

Updated on 27-November-2014

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• IG CR3
  • 1ido – hIG I domain + Mg – human
    
  • 1jlm - hIG I domain + Mn
    
• IG CD11a or IG α-L
  • 1lfa - hIG I domain + Mn
    
  • 1zon - hIG I domain
    
  • 1zoo, 1zop, 3f74 - hIG I domain + Mg
    
  • 1mq9 - hIG I domain (mutant) + Mn
    
  • 1mjn - hIG I domain (mutant) + Mg
    
  • 1mqa - hIG I domain (mutant)
    
  • 2k8o – hIG cytoplasmic domain (mutant) – NMR
    
• IG CD11a complexes
  • 1cqp - hIG I domain + lovastatin + Mg
    
  • 1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
    
  • 1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
    
  • 1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
    
  • 2o7n, 3m6f - hIG I domain + antagonist
    
  • 1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
    
  • 4ixd - hIG I domain + activator + Mg
    
  • 3f78 - hIG I domain + anesthetic + Mg
    
  • 3eoa, 3eob - hIG I domain + antibody
    
  • 3hi6 - hIG I domain (mutant) + antibody + Mn
    
• IG CD11b
  • 1bho - hIG I domain + Mg
    
  • 1bhq - hIG I domain + Cd
    
  • 1m1u - hIG I domain (mutant) + Ca
    
  • 1n9z - hIG I domain (mutant) + Mg
    
  • 1idn, 1na5 - hIG I domain
    
  • 1mf7 - hIG I domain (mutant)
• IG CD11c
  • 1n3y - hIG I domain (mutant)
• IG α-1 (CD49a)
  • 1ck4 - rIG I domain – rat
    
  • 4a0q - hIG I domain (mutant) + Mg
    
  • 2l8s - hIG transmembrane domain – NMR
    
  • 1mhp - rIG I domain (mutant) + antibody + Mn
    
  • 2b2x - rIG I domain (mutant) + antibody + Mg
    
  • 2m32 - hIG I domain + collagen peptide
    
• IG α-2 (CD49b)
  • 1dzi, 4bj3 - hIG I domain + collagen peptide
    
  • 1v7p - hIG I domain (mutant) + EMS16 + Mn
    
• IG α-2b
  • 2k1a - hIG transmembrane domain – NMR
    
• IG α-1 β-1 (CD49a-CD49b)
  • 1qc5, 1qcy - hIG I domain (mutant) + Mg
    
  • 1pt6 - hIG I domain + Mg
    
• IG α-2 (CD49b) β
  • 1aox - hIG I domain (mutant) + Mg
    
  • 1s4w - hIG cytoplasmic domain]] - NMR
    
• IG α-2b β-3 (CD61)
  • 1kup, 1kuz – hIG proximal domain – NMR
    
  • 1m8o - hIG cytoplasmic domain – NMR
    
  • 4cak – hIG – Cryo-EM
    
  • 2k9j, 2knc - hIG transmembrane domain – NMR
    
  • 1tye, 3fcu, 3fcs – hIG + Mg
    
  • 3fc3 – hIG (mutant) + Mg
    
  • 2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig, 3zdx, 3zdy, 3zdz, 3ze0, 3ze1, 3ze2 – hIG headpiece + antibody + Mg
    
  • 2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
    
  • 2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg
    
• IG α-4

• • 4irz - hIG + antibody
    
• IG α-4 (CD49d) β-7
  • 3v4p - hIG headpiece (mutant) + antibody + Mg
    
  • 3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
    
• IG α-5 (CD49e) β-1 (CD29)
  • 3vi3 - hIG headpiece + antibody + Mg
    
  • 3vi4 - hIG headpiece + antibody + peptide + Mg
    
• IG α-5 (CD49e) β-3 (CD61)
  • 3ije – hIG + Ca
    
  • 1m1x - hIG extracellular domain + Mn
    
  • 1u8c – hIG psi domain + Ca
    
  • 1jv2 - hIG I domain + platelet membrane glycoprotein IIIA + Ca
    
  • 1l5g - hIG I domain + tripeptide + Mn
    
• IG α-M
  • 3q3g, 3qa3 – hIG + antibody
    
  • 2lke, 2lkj – hIG cytoplasmic domain – NMR
    
• IG α-X
  • 2luv – hIG cytoplasmic domain – NMR
    
• IG α-X β-2 (CD18)
  • 3k6s, 3k71, 3k72 – hIG + Mg
    
  • 4neh, 4nen – hIG (mutant) + Mg
    
• IG α-V β-3
  • 4g1e, 4g1m – hIG + Ni
    
• IG β-1D
  • 3g9w – hIG cytoplasmic tail + talin 2 F2-F3 domain
    
• IG β-2 (CD18)
  • 2p26, 2p28 – hIG phe2 + phe3 domains
    
  • 1yuk – hIG chain A PSI domain + chain B I-EGF domain
    
• IG β-3 (CD61)
  • 1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
    
  • 2rmz, 2rn0 – hIG transmembrane domain – NMR
    
  • 2l91 - hIG transmembrane domain (mutant) – NMR
    
  • 2l1c – hIG cytoplasmic tail + SHC
    
• IG β-4 (CD104)
  • 2f7q, 3f7r, 1qg3, 3f7q - hIG fibronectin type III domain
    
  • 2yrz – hIG fibronectin type III domain – NMR
    
  • 3f7p - hIG fibronectin type III domain + plectin-1 + Ca
    
  • 3fq4, 3fso, 3h6a – hIG Calx-β domain

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Michal Harel, Alexander Berchansky