Spindlin

spinqualitylabelsall models Human spindlin-1 (skyblue) complex with histone H3 peptide (wheat) containing trimethyl lysine, MPD, Mg+2 (green) and Cl- (green) ions (PDB code 4mzg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Spindlin-1 (SPIN1) is a Tudor-like domain-containing protein which is a histone methylation effector protein and facilitates the expression of rRNA genes. SPIN1 senses a cis-tail histone H3 methylation pattern. Spindlin-2B is involved in the regulation of cell cycle progression. Spindlin-4 binds trimethylated histone H3K4. Relevance SPIN1 is implicated in liposarcoma and its inhibitors may represent a novel therapeutic strategy. Structural highlights The crystal complex of SPIN1 and histone H3 peptide shows the encapsulation of the histone trimethyllysine and its Arg in hydrophobic pockets of SPIN1.

3D Structures of spindlin

Updated on 14-August-2024

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• Spindlin-1
  • 2ns2 – hSPIN1 – human
    
  • 4mzg, 4mzh, 4mzf, 4h75, 5y5w, 7bqz, 7bu9 – hSPIN1 + histone peptide
    
  • 5jsg, 5jsj, 6i8b, 6i8l, 6i8y, 6qpl, 7ocb – hSPIN1 + inhibitor
    
  • 7e9m, 7ea1 – hSPIN1 + SPIN-DOC
    
  • 7cna – hSPIN1 + SPIN-DOC + inhibitor
    
  • 8gtx – hSPIN1 + HBx
    
• Spindlin-2B
  • 5lug – hSPIN2B + peptide
    
• Spindlin-3
  • 5a1h – hSPIN3
    
• Spindlin-4
  • 4uy4 – hSPIN4 + histone peptide
    

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