2gf5 | pdb_00002gf5
Structure of intact FADD (MORT1)
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Overview
The structure of FADD has been solved in solution, revealing that the, death effector domain (DED) and death domain (DD) are aligned with one, another in an orthogonal, tail-to-tail fashion. Mutagenesis of FADD and, functional reconstitution with its binding partners define the interaction, with the intracellular domain of CD95 and the prodomain of procaspase-8, and reveal a self-association surface necessary to form a productive, complex with an activated "death receptor." The identification of a, procaspase-specific binding surface on the FADD DED suggests a, preferential interaction with one, but not both, of the DEDs of, procaspase-8 in a perpendicular arrangement. FADD self-association is, mediated by a "hydrophobic patch" in the vicinity of F25 in the DED. The, structure of FADD and its functional characterization, therefore, illustrate the architecture of key components in the death-inducing, signaling complex.
About this Structure
2GF5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of FADD and its mode of interaction with procaspase-8., Carrington PE, Sandu C, Wei Y, Hill JM, Morisawa G, Huang T, Gavathiotis E, Wei Y, Werner MH, Mol Cell. 2006 Jun 9;22(5):599-610. PMID:16762833
Page seeded by OCA on Mon Nov 12 22:18:08 2007
