11ny | pdb_000011ny

Crystal Structure of viral OTU domain protease from Tacheng Tick Virus 1

spinqualitylabelsall models 11ny, resolution 1.37Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 11ny is a 1 chain structure with sequence from Orthonairovirus tachengense. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.37Å Ligands: SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0B5KXW6_9VIRU Publication Abstract from PubMed Tick-borne negative-sense single-stranded RNA nairoviruses represent a significant global public-health threat. Over the past decade, discoveries of new orthonairoviruses and norwaviruses have surged. Many of these have been observed to cause febrile illness in humans or have been found in vectors that carry other human diseases. All orthonairoviruses encode a viral homologue of the ovarian tumor protease (OTU) superfamily, which is part of the l-protein, and the OTU is conserved in the Norwavirus genus. OTUs exhibit varying levels of deubiquitinating (DUB) and deISGylating activities that facilitate viral immune evasion, establishing them as key virulence factors. Here, these activities from emerging Songling, Yezo, Tacheng tick virus 1, and Pacific Coast Tick orthonairoviruses, as well as the Beiji norwavirus, were investigated. This analysis reveals a diverse range of DUB and human deISGylase enzymatic activities in the previously uncharacterized viral groups. This includes unexpected OTU human deISGylating activity and suggests that OTUs possess functions beyond their established DUB and deISGylating roles. Additionally, the molecular basis of these activities, or the absence thereof, is explored through X-ray crystallographic structures of viral OTUs encoded by four orthonairoviruses and one norwavirus. The biochemical and structural insights provide a path forward for predicting OTU activity among current and emerging nairoviruses. Insights into the Structure and Function of the OTU Protease Virulence Factors from Emerging Human Nairoviruses.,Gonzalez DS, Jalf A, Moresco V, Garcia J, Jaroszewski L, Matta D, Nguyen J, Torres B, Bergeron E, Godzik A, Pegan SD ACS Infect Dis. 2026 Jul 13. doi: 10.1021/acsinfecdis.6c00320. PMID:42439547 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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