1o0j | pdb_00001o0j

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

HUMAN T-CELL LEUKEMIA VIRUS TYPE I PROTEASE (HTLV-I) WITH BOUND CAPSID/NUCLEOCAPSID (CA/NC) SUBSTRATE

spinqualitylabelsall models 1o0j Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, PDBsum, ProSAT Publication Abstract from PubMed Sequence alignment of human T-lymphotropic virus type I (HTLV-I) protease and other retroviral proteases reveals that the leukemia virus proteases contain residues at the C-terminus that are absent in the other proteases. We have prepared a mutant of HTLV-I protease that does not contain the 10 C-terminal residues and demonstrated that the catalytic efficiency of cleavage of a peptide substrate is unaffected. The 10 C-terminal residues of HTLV-I protease are not necessary for enzymatic activity.,Herger BE, Mariani VL, Dennison K, Shuker SB Biochem Biophys Res Commun. 2004 Aug 6;320(4):1306-8. PMID:15303275 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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