1um7 | pdb_00001um7

Solution structure of the third PDZ domain of synapse-associated protein 102

spinqualitylabelsall models 1um7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1um7 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Disease DLG3_HUMAN Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300850. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Function DLG3_HUMAN Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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