| Structural highlights
Function
VGR1A_PSEAE Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:21325275, PubMed:24794869). Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1 (PubMed:26894531). Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity (PubMed:30177742).[1] [2] [3] [4]
References
- ↑ Hachani A, Lossi NS, Hamilton A, Jones C, Bleves S, Albesa-Jove D, Filloux A. Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins. J Biol Chem. 2011 Apr 8;286(14):12317-27. doi: 10.1074/jbc.M110.193045. Epub 2011 , Feb 16. PMID:21325275 doi:https://dx.doi.org/10.1074/jbc.M110.193045
- ↑ Hachani A, Allsopp LP, Oduko Y, Filloux A. The VgrG proteins are "a la carte" delivery systems for bacterial type VI effectors. J Biol Chem. 2014 Jun 20;289(25):17872-84. doi: 10.1074/jbc.M114.563429. Epub , 2014 May 2. PMID:24794869 doi:https://dx.doi.org/10.1074/jbc.M114.563429
- ↑ Spinola-Amilibia M, Davo-Siguero I, Ruiz FM, Santillana E, Medrano FJ, Romero A. The structure of VgrG1 from Pseudomonas aeruginosa, the needle tip of the bacterial type VI secretion system. Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):22-33. doi: , 10.1107/S2059798315021142. Epub 2016 Jan 1. PMID:26894531 doi:https://dx.doi.org/10.1107/S2059798315021142
- ↑ Quentin D, Ahmad S, Shanthamoorthy P, Mougous JD, Whitney JC, Raunser S. Mechanism of loading and translocation of type VI secretion system effector Tse6. Nat Microbiol. 2018 Sep 3. pii: 10.1038/s41564-018-0238-z. doi:, 10.1038/s41564-018-0238-z. PMID:30177742 doi:https://dx.doi.org/10.1038/s41564-018-0238-z
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