2aa4 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NANK_ECOLI Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. Has also low level glucokinase activity in vitro.[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Plumbridge J, Vimr E. Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli. J Bacteriol. 1999 Jan;181(1):47-54. PMID:9864311
↑Miller BG, Raines RT. Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Biochemistry. 2004 Jun 1;43(21):6387-92. PMID:15157072 doi:https://dx.doi.org/10.1021/bi049424m
↑Larion M, Moore LB, Thompson SM, Miller BG. Divergent evolution of function in the ROK sugar kinase superfamily: role of enzyme loops in substrate specificity. Biochemistry. 2007 Nov 27;46(47):13564-72. Epub 2007 Nov 3. PMID:17979299 doi:https://dx.doi.org/10.1021/bi700924d
