2mfm | pdb_00002mfm

Solution structure of the C-terminally encoded peptide of the plant parasitic nematode Meloidogyne hapla - CEP11

spinqualitylabelsall models 2mfm Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mfm is a 1 chain structure with sequence from Meloidogyne hapla. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 10 models Ligands: HZP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G7K427_MEDTR Publication Abstract from PubMed The C-terminally Encoded Peptide (CEP) family of regulatory peptides controls root development in vascular plants. Here, we present the first NMR structures of CEP. We show that root-knot nematode (RKN: Meloidogyne spp.) also encodes CEP, presumably to mimic plant CEP as part of their stereotypic, parasitic interaction with vascular plants. Molecular dynamics simulations of plant- and nematode-encoded CEP displaying known posttranslational modifications (PTM) provided insight into the structural effects of PTM and the conformational plasticity and rigidity of CEP. Potential mechanisms of action are discussed with respect to the structure and sampling of conformational space. Solution NMR studies of the plant peptide hormone CEP inform function.,Bobay BG, Digennaro P, Scholl E, Imin N, Djordjevic MA, McK Bird D FEBS Lett. 2013 Dec 11;587(24):3979-85. doi: 10.1016/j.febslet.2013.10.033. Epub , 2013 Nov 5. PMID:24211833 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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