2mfp

Solution structure of the circular g-domain analog from the wheat metallothionein Ec-1

spinqualitylabelsall models 2mfp Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mfp is a 1 chain structure with sequence from Triticum aestivum. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 20 models Ligands: CD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function EC1_WHEAT Binds 5 molecules of zinc. May have a role in Zn(2+) homeostasis during embryogenesis. Publication Abstract from PubMed The first cyclic analog of a metallothionein (MT) was prepared and analyzed by UV and (magnetic) circular dichroism spectroscopy, ESI-MS as well as NMR spectroscopy. Results reveal that the evaluated cyclic g-Ec-1 domain of the wheat MT Ec-1 retains its ability to coordinate two Zn(II) or Cd(II) ions and adopts a three-dimensional structure that is highly similar to the one of the linear wild-type form. However, the reduced flexibility of the protein backbone facilitates structure solution significantly and results in a certain stabilization of metal binding to the protein. Solution Structure of the Circular gamma-Domain Analog from the Wheat Metallothionein Ec-1.,Tarasava K, Johannsen S, Freisinger E Molecules. 2013 Nov 21;18(11):14414-29. doi: 10.3390/molecules181114414. PMID:24284492 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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