2mgr

Structure of Plasmodium Yoelii Merozoite Surface Protein 1 - C-terminal Domain, E28K mutant

spinqualitylabelsall models 2mgr Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2mgr is a 1 chain structure with sequence from Plasmodium yoelii yoelii. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MSP1_PLAYO Publication Abstract from PubMed Merozoite surface protein 1 (MSP1) has been identified as a target antigen for protective immune responses against asexual blood stage malaria, but effective vaccines based on MSP1 have not been developed so far. We have modified the sequence of Plasmodium yoelii MSP119 (the C-terminal region of the molecule) and examined the ability of the variant proteins to bind protective monoclonal antibodies and to induce protection by immunization. In parallel, we examined the structure of the protein and the consequences of the amino acid changes. Naturally occurring sequence polymorphisms reduced the binding of individual protective antibodies, indicating that they contribute to immune evasion, but immunization with these variant proteins still provided protective immunity. One variant that resulted in the localized distortion of a loop close to the N-terminus of MSP119 almost completely ablated protection by immunization, indicating the importance of this region of MSP119 as a target for protective immunity and in vaccine development. The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design.,Curd RD, Birdsall B, Kadekoppala M, Ogun SA, Kelly G, Holder AA Open Biol. 2014 Jan 8;4(1):130091. doi: 10.1098/rsob.130091. PMID:24403012 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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