2n7s | pdb_00002n7s

Solution Structure of Leptospiral LigA4 Big Domain

spinqualitylabelsall models 2n7s Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2n7s is a 1 chain structure with sequence from Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130. This structure supersedes the now removed PDB entry 2n2i. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q72V39_LEPIC Publication Abstract from PubMed Pathogenic Leptospiraspecies express immunoglobulin-like proteins which serve as adhesins to bind to the extracellular matrices of host cells. Leptospiral immunoglobulin-like protein A (LigA), a surface exposed protein containing tandem repeats of bacterial immunoglobulin-like (Big) domains, has been proved to be involved in the interaction of pathogenic Leptospira with mammalian host. In this study, the solution structure of the fourth Big domain of LigA (LigA4 Big domain) from Leptospira interrogans was solved by nuclear magnetic resonance (NMR). The structure of LigA4 Big domain displays a similar bacterial immunoglobulin-like fold compared with other Big domains, implying some common structural aspects of Big domain family. On the other hand, it displays some structural characteristics significantly different from classic Ig-like domain. Furthermore, Stains-all assay and NMR chemical shift perturbation revealed the Ca(2+) binding property of LigA4 Big domain. Solution structure of leptospiral LigA4 Big domain.,Mei S, Zhang J, Zhang X, Tu X Biochem Biophys Res Commun. 2015 Nov 13;467(2):288-92. doi:, 10.1016/j.bbrc.2015.09.170. Epub 2015 Oct 9. PMID:26449456 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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