2ydp

Structure of the E242A mutant of the alpha-l-arabinofuranosidase arb93a from fusarium graminearum in complex with an iminosugar inhibitor

spinqualitylabelsall models 2ydp, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2ydp is a 3 chain structure with sequence from Fusarium graminearum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.85Å Ligands: AHR, CA, EDG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B8ZY56_GIBZA Publication Abstract from PubMed As part of continued efforts to understand the mechanisms of 1,5-alpha-l-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An iminosugar analogue of arabinobiose was found to be a good inhibitor of the arabinanase Arb93A from Fusarium graminearum. Structures were determined for complexes of this inhibitor with wild-type Arb93A and a catalytically inactive mutant. alpha-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors.,Goddard-Borger ED, Carapito R, Jeltsch JM, Phalip V, Stick RV, Varrot A Chem Commun (Camb). 2011 Sep 14;47(34):9684-6. Epub 2011 Jul 20. PMID:21773614 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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