3ble is a 1 chain structure with sequence from Leptospira interrogans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
CIMA_LEPIN Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate (PubMed:15292141, PubMed:18498255, PubMed:19351325). Shows strict substrate specificity for pyruvate. Cannot use alpha-ketoisovalerate, alpha-ketobutyrate, alpha-ketoisocaproate, alpha-ketoglutarate or glyoxylate (PubMed:15292141, PubMed:18498255).[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G. Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. J Bacteriol. 2004 Aug;186(16):5400-9. PMID:15292141 doi:10.1128/JB.186.16.5400-5409.2004
↑Ma J, Zhang P, Zhang Z, Zha M, Xu H, Zhao G, Ding J. Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans. Biochem J. 2008 Oct 1;415(1):45-56. PMID:18498255 doi:https://dx.doi.org/10.1042/BJ20080242
↑Zhang P, Ma J, Zhang Z, Zha M, Xu H, Zhao G, Ding J. Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans. Biochem J. 2009 Jun 12;421(1):133-43. PMID:19351325 doi:10.1042/BJ20090336
