3klo | pdb_00003klo

Vibrio cholerae VpsT bound to c-di-GMP

spinqualitylabelsall models 3klo, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3klo is a 4 chain structure with sequence from Vibrio cholerae O1 biovar El Tor. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.802Å Ligands: C2E, TAR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9KKZ8_VIBCH Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Microorganisms can switch from a planktonic, free-swimming life-style to a sessile, colonial state, called a biofilm, which confers resistance to environmental stress. Conversion between the motile and biofilm life-styles has been attributed to increased levels of the prokaryotic second messenger cyclic di-guanosine monophosphate (c-di-GMP), yet the signaling mechanisms mediating such a global switch are poorly understood. Here we show that the transcriptional regulator VpsT from Vibrio cholerae directly senses c-di-GMP to inversely control extracellular matrix production and motility, which identifies VpsT as a master regulator for biofilm formation. Rather than being regulated by phosphorylation, VpsT undergoes a change in oligomerization on c-di-GMP binding. Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP.,Krasteva PV, Fong JC, Shikuma NJ, Beyhan S, Navarro MV, Yildiz FH, Sondermann H Science. 2010 Feb 12;327(5967):866-8. PMID:20150502 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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