| Structural highlights
3qb5 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 2.95Å |
| Ligands: | CL, MN, NA, PO4, SO4 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
TSN_HUMAN DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.[1] [2] Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.[3] [4]
References
- ↑ Kasai M, Matsuzaki T, Katayanagi K, Omori A, Maziarz RT, Strominger JL, Aoki K, Suzuki K. The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome. J Biol Chem. 1997 Apr 25;272(17):11402-7. PMID:9111049
- ↑ Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H. Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol. 2011 May 8. PMID:21552258 doi:10.1038/nsmb.2032
- ↑ Kasai M, Matsuzaki T, Katayanagi K, Omori A, Maziarz RT, Strominger JL, Aoki K, Suzuki K. The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome. J Biol Chem. 1997 Apr 25;272(17):11402-7. PMID:9111049
- ↑ Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H. Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol. 2011 May 8. PMID:21552258 doi:10.1038/nsmb.2032
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