43sn | pdb_000043sn

Alpha-7 nicotinic acetylcholine receptor bound to inhibitory bicyclic peptide KP1877 in a resting state

spinqualitylabelsall models 43sn, resolution 2.71Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 43sn is a 10 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.71Å Ligands: NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Peptides targeting the alpha7 nicotinic acetylcholine receptor (alpha7-nAChR) represent promising candidates for therapeutic and chemical probe development. Here, we identified a novel bicyclic peptide KP1877 via phage-displayed peptide library screening followed by chemical synthesis of active analogs. Structural characterization reveals KP1877 adopts a unique bicyclic conformation distinct from known natural alpha7-nAChR-targeting peptides, and exerts potent inhibitory effect by stabilizing the closed, non-conducting state of the receptor via orthosteric binding. Screening, synthesis and structural characterization of a novel bicyclic peptide inhibiting alpha7 nicotinic acetylcholine receptor.,Yang X, Cui K, Cao X, Chen H, Tian C, Sun D Chem Commun (Camb). 2026 Sep 1;62(68):17041-17045. doi: 10.1039/d6cc03853k. PMID:42574057 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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