5c9b | pdb_00005c9b

Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii

spinqualitylabelsall models 5c9b, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5c9b is a 4 chain structure with sequence from Rickettsia conorii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.4Å Ligands: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q92FY8_RICCN Publication Abstract from PubMed The crystal structures of two constructs of RC1339/APRc from Rickettsia conorii, consisting of either residues 105-231 or 110-231 followed by a His tag, have been determined in three different crystal forms. As predicted, the fold of a monomer of APRc resembles one-half of the mandatory homodimer of retroviral pepsin-like aspartic proteases (retropepsins), but the quaternary structure of the dimer of APRc differs from that of the canonical retropepsins. The observed dimer is most likely an artifact of the expression and/or crystallization conditions since it cannot support the previously reported enzymatic activity of this bacterial aspartic protease. However, the fold of the core of each monomer is very closely related to the fold of retropepsins from a variety of retroviruses and to a single domain of pepsin-like eukaryotic enzymes, and may represent a putative common ancestor of monomeric and dimeric aspartic proteases. Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.,Li M, Gustchina A, Cruz R, Simoes M, Curto P, Martinez J, Faro C, Simoes I, Wlodawer A Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2109-18. doi:, 10.1107/S1399004715013905. Epub 2015 Sep 30. PMID:26457434 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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