5elh | pdb_00005elh
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Crystal structure of mouse Unkempt zinc fingers 1-3 (ZnF1-3), bound to RNA
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Structural highlights
FunctionUNK_MOUSE Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).[1] References
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This page was last modified 12:28, 6 March 2024.