5fsc

Structure of tectonin 2 from Laccaria bicolor in complex with allyl- alpha_4-methyl-mannoside

spinqualitylabelsall models 5fsc, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5fsc is a 2 chain structure with sequence from Laccaria bicolor S238N-H82. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.95Å Ligands: G8Z, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B0CZL6_LACBS Publication Abstract from PubMed Innate immunity is the first line of defense against pathogens and predators. To initiate a response, it relies on the detection of invaders, where lectin-carbohydrate interactions play a major role. O-Methylated glycans were previously identified as non-self epitopes and conserved targets for defense effector proteins belonging to the tectonin superfamily. Here, we present two crystal structures of Tectonin 2 from the mushroom Laccaria bicolor in complex with methylated ligands, unraveling the molecular basis for this original specificity. Furthermore, they revealed the formation of a ball-shaped tetramer with 24 binding sites distributed at its surface, resembling a small virus capsid. Based on the crystal structures, a methylation recognition motif was identified and found in the sequence of many tectonins from bacteria to human. Our results support a key role of tectonins in innate defense based on a distinctive and conserved type of lectin-glycan interaction. Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense.,Sommer R, Makshakova ON, Wohlschlager T, Hutin S, Marsh M, Titz A, Kunzler M, Varrot A Structure. 2018 Mar 6;26(3):391-402.e4. doi: 10.1016/j.str.2018.01.003. Epub 2018, Feb 1. PMID:29398527 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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