5fzw | pdb_00005fzw

High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1h

spinqualitylabelsall models 5fzw Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5fzw is a 1 chain structure with sequence from Scytodes thoracica. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 20 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function U31H_SCYTH Probable insect neurotoxin with ion channel impairing activity (Probable). Does not show activity on 45 human receptors from 9 families (5-hydroxytryptamine, adrenergic, dopamine, muscarinic, histamine, neurotransmitter, opioid, sigma, and gaba(A) receptors) (PubMed:27227898). In vivo, when mixed with U3-SYTX-Sth1a does not cause paralytic or lethal activity when injected into crickets (PubMed:27227898). It is noteworthy that crickets are evolutionarily distant from prey species (PubMed:27227898). Publication Abstract from PubMed We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target. Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica.,Ariki NK, Munoz LE, Armitage EL, Goodstein FR, George KG, Smith VL, Vetter I, Herzig V, King GF, Loening NM PLoS One. 2016 May 26;11(5):e0156291. doi: 10.1371/journal.pone.0156291., eCollection 2016. PMID:27227898 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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