Structural highlights
Function
NSP1_ROTS4 Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.[HAMAP-Rule:MF_04088][1] [2] [3] [4] [5]
See Also
References
- ↑ Barro M, Patton JT. Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4114-9. PMID:15741273 doi:10.1073/pnas.0408376102
- ↑ Graff JW, Ewen J, Ettayebi K, Hardy ME. Zinc-binding domain of rotavirus NSP1 is required for proteasome-dependent degradation of IRF3 and autoregulatory NSP1 stability. J Gen Virol. 2007 Feb;88(Pt 2):613-620. PMID:17251580 doi:10.1099/vir.0.82255-0
- ↑ Barro M, Patton JT. Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7. J Virol. 2007 May;81(9):4473-81. PMID:17301153 doi:10.1128/JVI.02498-06
- ↑ Lutz LM, Pace CR, Arnold MM. Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases. J Virol. 2016 Jun 10;90(13):6036-48. PMID:27099313 doi:10.1128/JVI.00704-16
- ↑ Zhao B, Shu C, Gao X, Sankaran B, Du F, Shelton CL, Herr AB, Ji JY, Li P. Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3403-12. doi:, 10.1073/pnas.1603269113. Epub 2016 Jun 2. PMID:27302953 doi:https://dx.doi.org/10.1073/pnas.1603269113
