5vh0 | pdb_00005vh0

RHCC in complex with pyrene

spinqualitylabelsall models 5vh0, resolution 2.06Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5vh0 is a 4 chain structure with sequence from Staphylothermus marinus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.055Å Ligands: 8P0, EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q54436_STAMA Publication Abstract from PubMed Polycyclic aromatic hydrocarbons (PAHs) are toxic, mutagenic and among the most damaging chemical compounds with regard to living organisms. Because of their persistence and wide distribution removal from the environment is an important challenge. Here we report a new Nano container matrix based on the deep sea archaea-derived RHCC-Nanotube (RHCC-NT), which rapidly and preferentially binds low molecular weight PAHs. Under controlled-laboratory conditions and using fluorescence spectroscopy in combination with X-ray crystallography and MD simulations, we quantified the real-time binding of low molecular weight PAHs (2-4 rings) to our substrate. Binding coefficients ranged from 5.4 +/- 1.6 (fluorene) to 32 +/- 7.0 muM (acenaphthylene) and a binding capacity of 85 pmoles PAH per mg RHCC-NT, or 2.12 mumoles in a standard 25 mg sampler. The uptake rate of pyrene was calculated to be 1.59 nmol/hrmol RHCC-NT (at 10 C). Our results clearly show that RHCC-NT is uniquely suited as a monitoring matrix for low molecular weight PAHs. Proteinaceous Nano container Encapsulate Polycyclic Aromatic Hydrocarbons.,McDougall M, Francisco O, Harder-Viddal C, Roshko R, Heide F, Sidhu S, Khajehpour M, Leslie J, Palace V, Tomy GT, Stetefeld J Sci Rep. 2019 Jan 31;9(1):1058. doi: 10.1038/s41598-018-37323-x. PMID:30705306 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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