6bka

Crystal Structure of Nitronate Monooxygenase from Cyberlindnera saturnus

spinqualitylabelsall models 6bka, resolution 1.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6bka is a 1 chain structure with sequence from Cyberlindnera mrakii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.65Å Ligands: 33O, CSD, FMN, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function 2NPD_CYBMR Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites. Publication Abstract from PubMed Nitronate monooxygenase (NMO) is an FMN-dependent enzyme that oxidizes the neurotoxin propionate 3-nitronate (P3N) and represents the best-known system for P3N detoxification in different organisms. The crystal structure of the first eukaryotic Class I NMO from Cyberlindnera saturnus (CsNMO) has been solved at 1.65 A resolution and refined to an R-factor of 14.0%. The three-dimensional structures of yeast CsNMO and bacterial PaNMO are highly conserved with the exception of three additional loops on the surface in the CsNMO enzyme and differences in four active sites residues. A PEG molecule was identified in the structure and formed extensive interactions with CsNMO, suggesting a specific binding site; however, 8% PEG showed no significant effect on the enzyme activity. This new crystal structure of a eukaryotic NMO provides insight into the function of this class of enzymes. Crystal structure of yeast nitronate monooxygenase from Cyberlindnera saturnus.,Agniswamy J, Reis RAG, Wang YF, Smitherman C, Su D, Weber I, Gadda G Proteins. 2018 Jan 31. doi: 10.1002/prot.25470. PMID:29383742 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Monooxygenase 3D structures

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