6row

Haemonchus galactose containing glycoprotein complex

spinqualitylabelsall models 6row, resolution 4.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6row is a 7 chain structure with sequence from Haemonchus contortus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.5Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function O76751_HAECO Publication Abstract from PubMed Roundworm parasite infections are a major cause of human and livestock disease worldwide and a threat to global food security. Disease control currently relies on anthelmintic drugs to which roundworms are becoming increasingly resistant. An alternative approach is control by vaccination and 'hidden antigens', components of the worm gut not encountered by the infected host, have been exploited to produce Barbervax, the first commercial vaccine for a gut dwelling nematode of any host. Here we present the structure of H-gal-GP, a hidden antigen from Haemonchus contortus, the Barber's Pole worm, and a major component of Barbervax. We demonstrate its novel architecture, subunit composition and topology, flexibility and heterogeneity using cryo-electron microscopy, mass spectrometry, and modelling. Importantly, we demonstrate that complexes with the same architecture are present in other Strongylid roundworm parasites including human hookworm. This suggests a common ancestry and the potential for development of a unified hidden antigen vaccine. Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites.,Scarff CA, Thompson RF, Newlands GFJ, Jamson AH, Kennaway C, da Silva VJ, Rabelo EM, Song CF, Trinick J, Smith WD, Muench SP PLoS Pathog. 2020 Apr 9;16(4):e1008465. doi: 10.1371/journal.ppat.1008465., eCollection 2020 Apr. PMID:32271834 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Pepsin

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