6ssd | pdb_00006ssd

Transaminase with PLP bound

spinqualitylabelsall models 6ssd, resolution 1.18Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ssd is a 1 chain structure with sequence from Streptomyces kaniharaensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.18Å Ligands: PLP, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A6I8WFW1_9ACTN Publication Abstract from PubMed ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin. Cycloserine is thought to inhibit PLP-dependent enzymes by irreversibly forming a PMP-isoxazole. We now report that ForI forms novel PMP-diketopiperazine derivatives following incubation with both d and l cycloserine. This unexpected result suggests chemical diversity in the chemistry of cycloserine inhibition. PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis.,Gao S, Liu H, de Crecy-Lagard V, Zhu W, Richards NGJ, Naismith JH Chem Commun (Camb). 2019 Nov 28;55(96):14502-14505. doi: 10.1039/c9cc06975e. PMID:31730149 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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