7ups | pdb_00007ups

Structural study of Legionella pneumophila effector DotY (Lpg0294)

spinqualitylabelsall models 7ups, resolution 2.43Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7ups is a 4 chain structure with sequence from Legionella pneumophila subsp. pneumophila str. Philadelphia 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.43Å Ligands: EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DOTY_LEGPH Component of the Dot/Icm type IVB secretion system (T4BSS), which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:32513920). Part of a subcomplex which recruits effector proteins and delivers them to the core transmembrane subcomplex (PubMed:32513920). DotY and DotZ play a role in effector translocation, but are not essential and do not influence the stability of the subcomplex main components (PubMed:34816517). The DotY/DotZ main function is to optimize secretion by modulating the delivery trajectory of the IcmSW module and the localization of the machinery to the poles (PubMed:34816517).

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