7xvi | pdb_00007xvi

pathogen effectors which are essential to cause plant disease by manipulating cellular processes in the host

spinqualitylabelsall models 7xvi, resolution 3.11Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7xvi is a 1 chain structure with sequence from Phytophthora infestans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.11Å Ligands: CD, EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A833T3B4_PHYIN Publication Abstract from PubMed Pathogens produce diverse effector proteins to manipulate host cellular processes. However, how functional diversity is generated in an effector repertoire is poorly understood. Many effectors in the devastating plant pathogen Phytophthora contain tandem repeats of the "(L)WY" motif, which are structurally conserved but variable in sequences. Here, we discovered a functional module formed by a specific (L)WY-LWY combination in multiple Phytophthora effectors, which efficiently recruits the serine/threonine protein phosphatase 2A (PP2A) core enzyme in plant hosts. Crystal structure of an effector-PP2A complex shows that the (L)WY-LWY module enables hijacking of the host PP2A core enzyme to form functional holoenzymes. While sharing the PP2A-interacting module at the amino terminus, these effectors possess divergent C-terminal LWY units and regulate distinct sets of phosphoproteins in the host. Our results highlight the appropriation of an essential host phosphatase through molecular mimicry by pathogens and diversification promoted by protein modularity in an effector repertoire. Pathogen protein modularity enables elaborate mimicry of a host phosphatase.,Li H, Wang J, Kuan TA, Tang B, Feng L, Wang J, Cheng Z, Sklenar J, Derbyshire P, Hulin M, Li Y, Zhai Y, Hou Y, Menke FLH, Wang Y, Ma W Cell. 2023 Jul 20;186(15):3196-3207.e17. doi: 10.1016/j.cell.2023.05.049. Epub , 2023 Jun 26. PMID:37369204 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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