Structural highlights
Function
HMNGT_SORBI Involved in the biosynthesis of the cyanogenic glucoside dhurrin. Prevents the dissociation and release of toxic hydrogen cyanide. Mandelonitrile, p-hydroxymandelonitrile, benzyl alcohol, benzoic acid and geraniol, but not hydroquinone(1,4-benzenediol), alpha-terpinol, linalool or farnesol are utilized as acceptor substrates. UDP-glucose, but not UDP-xylose or UDP-glucuronic acid can be used as sugar donor.[1] [2] [3]
References
- ↑ Jones PR, Moller BL, Hoj PB. The UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase that catalyzes the last step in synthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor. Isolation, cloning, heterologous expression, and substrate specificity. J Biol Chem. 1999 Dec 10;274(50):35483-91. doi: 10.1074/jbc.274.50.35483. PMID:10585420 doi:https://dx.doi.org/10.1074/jbc.274.50.35483
- ↑ Tattersall DB, Bak S, Jones PR, Olsen CE, Nielsen JK, Hansen ML, Hoj PB, Moller BL. Resistance to an herbivore through engineered cyanogenic glucoside synthesis. Science. 2001 Sep 7;293(5536):1826-8. doi: 10.1126/science.1062249. Epub 2001 Jul, 26. PMID:11474068 doi:https://dx.doi.org/10.1126/science.1062249
- ↑ Kristensen C, Morant M, Olsen CE, Ekstrom CT, Galbraith DW, Moller BL, Bak S. Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1779-84. doi:, 10.1073/pnas.0409233102. Epub 2005 Jan 21. PMID:15665094 doi:https://dx.doi.org/10.1073/pnas.0409233102
